Research Scientist I – Dr. Patrick Hwu Lab

Working at Moffitt is both a career and a mission: to contribute to the prevention and cure of cancer.

As the only National Cancer Institute-designated Comprehensive Cancer Center based in Florida, Moffitt employs some of the best and brightest minds from around the world. Join a dedicated team of nearly 11,000 who are shaping the future we envision. Moffitt has been recognized as a Best and Brightest Company to Work For in the Nation and is continually named one of the Tampa Bay Times’ Top Workplaces.

Summary

The Hwu Lab develops genetically engineered T-cell therapies and novel immune receptors to improve tumor recognition, overcome immune suppression and combat metabolic stress within the tumor microenvironment, ultimately enhancing the efficacy of cellular immunotherapy against difficult-to-treat solid cancers.

Position Highlights:

• Conduct innovative, hypothesis-driven research focused on novel CART designs, T-cell engineering strategies, and approaches to overcome biological barriers that limit efficacy of adoptive cell therapies in solid tumors.
• Apply an integrated approach combining molecular and cellular biology, cancer genetics, immunology, and preclinical cancer models.
• Lead and contribute to independent research projects investigating mechanisms of T-cell activation, persistence, dysfunction, tumor resistance, and immune suppression in the context of engineered T-cell therapies.
• Develop and evaluate novel therapeutic strategies with potential for translational and clinical applications.
• Contribute to peer-reviewed publications, grant applications, scientific presentations, and intellectual property, as well as the mentorship of junior researchers.

The Ideal Candidate:

• Demonstrated experience in T-cell biology and CAR-T or TCR-T cell engineering, including lentiviral and/or retroviral gene modification of primary T cells or other immune cells.

• Proficiency in multiparameter flow cytometry, including panel design, acquisition, compensation, analysis, and interpretation of high-dimensional datasets.
• Demonstrated experience developing and applying functional assays to evaluate immune-cell activation, cytotoxicity, cytokine production, and proliferation.
• Strong experience with molecular and cellular biology techniques.
• Experience integrating and interpreting flow cytometry, molecular, functional, and/or multi-omics datasets to address complex biological questions.
• Experience analyzing and visualizing data using GraphPad Prism, R, Python, or equivalent software.
• Strong record of scientific productivity, including peer-reviewed publications and/or contributions to intellectual property.
• Strong analytical, critical-thinking, problem-solving, organizational, and scientific communication skills.
• Demonstrated ability to work independently while contributing effectively to a collaborative, multidisciplinary research environment.
• Experience supervising or mentoring graduate students, research assistants, postdoctoral fellows, or other junior researchers.

• Commitment to scientific rigor, reproducibility, ethical research practices, and continuous professional development.

Responsibilities:

• Design and conduct and lead independent research projects.
• Develop, optimize, and characterize genetically engineered T-cell products using lentiviral and retroviral gene-transfer approaches.
• Perform molecular and cellular analysis
• Integrate multi-omics data
• Analyze and interpret data
• Maintain research records
• Contribute to publications and grant applications.
• Mentor junior researchers and communicating scientific concepts effectively
• Support other laboratory projects
• Collaborating across disciplinary teamwork

Credentials and Qualifications:

• PhD., M.D. or equivalent doctoral degree in Immunology, cancer biology, molecular biology, cell biology, biomedical sciences, or a related field.
• A minimum of two (2) year’s total experience as a postdoctoral fellow or as a post-PhD science experience in T-cell immunology and/or cancer immunotherapy.
• Demonstrated experience with preclinical tumor models and supporting or performing in-vivo therapeutic studies.
• Moffitt Cancer Center is an NCI-designated comprehensive Cancer Center in Tampa, Florida. Tampa is an ideal choice for those seeking opportunities in a rapidly growing metropolitan city. With its vibrant economy and diverse culture, Tampa Bay offers a unique blend of urban sophistication and natural beauty. Join the many who have already discovered what makes Tampa one of the fastest-growing metropolitan cities in the US.

Moffitt Team Members are:

· Eligible for an annual Team Member Incentive

· Eligible for an annual Team Member Merit Increase

· Have an Inclusive Benefits package - Health, Financial, & Lifestyle coverage

How to Apply: Interested applicants should send a single PDF file that includes a cover letter summarizing their research training and accomplishments, a personal statement of scientific interests and goals, current CV with recent publications, and contact information for three references to Dr. Patrick Hwu.

Salary Range

Salary ranges posted for this position represent the expected base pay range for the role. Actual compensation may vary based on location and a variety of job-related factors, including experience, skills, education, and internal equity among Team Members in similar positions.

We are committed to maintaining fair and equitable pay practices and regularly review compensation to ensure alignment across our workforce.

Moffitt Career Site

If you have the vision, passion, and dedication to contribute to our mission,

then we have a place for you!

1. Equal Employment Opportunity

Moffitt Cancer Center is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, or protected veteran or disabled status. We seek candidates whose skills, and personal and professional experience, have prepared them to contribute to our commitment to diversity and excellence.

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From the posting on Moffitt Cancer Center's job site. Read the original before you apply.